Quantifying mitochondrial viscosity changes by an AIE probe during drug therapy
Jinghui Qiao1, Yueyao Liu2, Zhigui Ma2
1Polymer Research Institute, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, PR China. zhaoxz@scu.edu.cn.
Abstract:
A novel viscosity-sensitive, mitochondrial-targeted AIE fluorescent probe, TPE-4TPP, was developed to quantify dynamic changes in mitochondrial viscosity induced by an anticancer drug. Using fluorescence lifetime as a bridge, a quantitative relationship between drug duration and mitochondrial viscosity was established.


