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Analysis of risk factors affecting psycho-behavioural development in children with short bowel syndrome
Yue Wang1, Li Yu1, Ruifei Zheng1
1Department of Neonatal Surgeries, Children's Hospital of Nanjing Medical University, Nanjing, China.
Insights
This study investigated psycho-behavioral development in children with short bowel syndrome (SBS), finding that liver function and surgical factors significantly influence development. These findings offer insights for future clinical interventions in SBS patients.
Area of Science:
- Pediatric Gastroenterology
- Developmental Psychology
- Clinical Research
Background:
- Short Bowel Syndrome (SBS) presents complex challenges for pediatric patients.
- Understanding the psycho-behavioral development in children with SBS is crucial for comprehensive care.
- Identifying factors influencing this development can guide targeted interventions.
Purpose of the Study:
- To track the psycho-behavioral development of children diagnosed with SBS.
- To identify and analyze factors that impact the psycho-behavioral development of these children.
Main Methods:
- Retrospective analysis of clinical data from 86 children with SBS.
- Assessment of psycho-behavioral development using the Ages and Stages Questionnaires, Third Edition (ASQ-3).
- Statistical analysis including Spearman's correlation, Kruskal Wallis H test, and logistic regression to identify risk factors.
Main Results:
- Liver function markers (total bilirubin, ALT, AST, direct bilirubin) were associated with motor and fine motor development.
- Intestinal failure-associated liver disease (IFALD) presence impacted communication development.
- Surgical factors like ileocecal junction preservation positively influenced communication, problem-solving, and personal-socialization.
- Absence of sepsis and presence of retinol-binding protein were protective factors for personal-socialization and communication.
Conclusions:
- Liver function, nutritional status, and surgical interventions are linked to psycho-behavioral development in children with SBS.
- Findings provide a basis for developing targeted clinical interventions and treatment strategies.
- Further research can refine understanding and improve outcomes for children with SBS.
Purpose:
The aim of this study is to follow up the psycho-behavioural development of children with SBS and to analyse the influencing factors affecting the children's psycho-behavioural development.
Methods:
Clinical information about 86 children with SBS was retrospectively collected through the hospital electronic medical record system. The ASQ-3 was used to assess the psycho-behavioural developmental outcomes of the children. Spearman's correlation coefficient, Kruskal Wallis H test, logistic regression analysis were used to find the risk factors affecting the psycho-behavioural development of the children through SPSS 27.0 statistical software.
Results:
Total bilirubin level was an influencing factor in gross motor (OR = 1.013, p = 0.010) and fine motor development (OR = 1.012, p = 0.044). ALT (OR = 1.007, p = 0.041) and AST (OR = 0.995, p = 0.021) were the influencing factors of gross motor development. High direct bilirubin (OR = 1.018, p = 0.034) was a risk factor for fine motor development. The presence or absence of IFALD (OR = 5.883, p = 0.034) during hospitalisation affected children's communication development. Preservation of the ileocecal junction during surgeries was beneficial for the development of communication (OR = 0.138, p = 0.007), problem-solving (OR = 0.117, p = 0.003), and personal-socialisation (OR = 0.119, p < 0.001). Absence of sepsis (OR = 0.227, p = 0.040) was a protective factor for the personal-socialisation development of the children. Retinol-binding protein was a protective factor in the communication (OR = 0.842, p = 0.012) and personal-socialisation (OR = 0.896, p = 0.014) domains of the children.
Conclusion:
Our study finds a possible association between the liver function, nutritional status, retention of the ileocecal junction during surgeries and psycho-behavioural development in children with SBS, providing recommendations for future clinical interventions and treatments.
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