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Serum folates in man.

K R Thien, J A Blair, R J Leeming

    Journal of Clinical Pathology
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    The study shows that the body

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    Area of Science:

    • Biochemistry
    • Microbiology
    • Human Physiology

    Background:

    • Folate compounds are essential for human health.
    • Understanding the bioavailability of different folate forms is crucial for nutrition and disease management.

    Purpose of the Study:

    • To evaluate the microbiological activity and in vivo bioavailability of various folate compounds.
    • To investigate factors influencing folate absorption and utilization in humans.

    Main Methods:

    • Aseptic microbiological assays using Lactobacillus casei, Streptococcus faecalis, and Pediococcus cerevisiae.
    • Analysis of serum folate levels in normal subjects and patients with various disorders.
    • Oral administration studies in humans to assess folate absorption and conversion.

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    Main Results:

    • 5-Methyl-5,6-dihydrofolate requires ascorbate for activity and is converted to 5-methyltetrahydrofolate in vivo.
    • 5-Methyltetrahydrofolate is absorbed by normal subjects and pernicious anemia patients but poorly by coeliac disease or leukemia patients.
    • Elevated 10-formyltetrahydrofolate levels were observed in coeliac disease, leukemia, rheumatoid arthritis, and schizophrenia.

    Conclusions:

    • The bioavailability of dietary folate compounds depends on gastric acidity and intestinal ascorbate levels.
    • Certain folate forms may be unavailable for metabolic utilization due to these factors.
    • This has implications for folate status in various gastrointestinal and systemic diseases.