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Investigating Microplastic Presence in Eye Drops Using Micro-Fourier Transform Infrared Spectroscopy

Geraldine Yang1, Jerome Ozkan1, Minas Coroneo1,2

  • 1University of New South Wales, Sydney, Australia ; and.

Cornea
|June 20, 2025
PubMed
Abstract

Insights

Microplastics (MPs) were found in commercial eye drops, raising health concerns. Further research is needed to identify sources and assess risks from these plastic particles in ocular medications.

Area of Science:

  • Ophthalmology
  • Environmental Health
  • Materials Science

Background:

  • Microplastics (MPs) are pervasive environmental contaminants with potential health implications.
  • The ocular surface is a potential route for MP exposure through contaminated medications.
  • Previous studies suggest MPs may cause ocular surface inflammation and damage.

Purpose of the Study:

  • To investigate the presence of microplastics (MPs) in commercially available eye drops.
  • To assess the potential for MP contamination in topical ocular medications.
  • To understand the pathways of MPs into ocular and systemic tissues.

Main Methods:

  • Analysis of 60 samples from 20 brands of commercial eye drops.
  • Identification of particles ≥20 μm using micro-Fourier Transform Infrared Spectroscopy.
  • Confirmation of MP identity against polymer and chemical databases.

Main Results:

  • Four microplastics (MPs) were identified in two eye drop samples.
  • Detected MPs included poly(1-dodecene) and poly(1-octene) films.
  • Additional non-MP particles, such as chemical catalysts, were also found.

Conclusions:

  • Commercial eye drops can contain microplastics (MPs) ≥20 μm.
  • The origin of MPs in eye drops (packaging or ingredients) requires further investigation.
  • Advanced techniques like micro-Raman spectroscopy are recommended for definitive MP analysis.
Keywords:
eye dropsmicro-Fourier Transform Infrared spectroscopymicroplasticsocular medications

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