Photoelectrochemical Iron-Nickel Synergistic Catalysis for C(sp3)-H and Dehydroxymethylative Acylation
Xiao Zhou1, Ping-Fu Zhong1, Zhuohua Li1
1State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China.
Abstract:
We developed an iron-nickel dual-catalytic system for efficient C(sp3)-H activation acylation of hydrocarbons and carboxylic acids under photoelectrochemical conditions. This system is based on ligand-to-metal charge transfer-mediated direct hydrogen atom transfer and is applicable to inert C(sp3)-H-containing compounds. It also enables dehydroxymethylative acylation of alcohols, both these two reactions demonstrating broad substrate scope and unconventional chemoselectivity. Gram-scale synthesis, flow chemistry, and mechanistic studies highlight its potential in sustainable C(acyl)-C bond formation.
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