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Related Experiment Video

Updated: May 12, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Sodium cromoglycate in ragweed-allergic conjunctivitis.

J Greenbaum, D Cockcroft, F E Hargreave

The Journal of Allergy and Clinical Immunology

|June 1, 1977

Summary

Sodium cromoglycate eye drops effectively treated ragweed-induced conjunctivitis. Patients using sodium cromoglycate (SCG) experienced significantly reduced eye symptoms and overall improvement compared to placebo.

Area of Science:

Ophthalmology
Allergology
Pharmacology

Background:

Seasonal allergic conjunctivitis (SAC) is often triggered by environmental allergens like ragweed pollen.
Effective management of SAC symptoms is crucial for patient quality of life.

Purpose of the Study:

To evaluate the efficacy of sodium cromoglycate (SCG) in treating ragweed pollen-induced conjunctivitis.
To compare SCG treatment against a placebo in a controlled clinical trial.

Main Methods:

A double-blind, noncrossover trial was conducted with 30 matched patients.
Patients received either a 4% sodium cromoglycate solution or a placebo, instilled into each eye four times daily.
Symptom scores and antihistamine use were recorded.

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Main Results:

The sodium cromoglycate group showed significantly lower eye symptom scores (p = 0.05).
All patients treated with SCG reported symptom improvement compared to the previous year (p < 0.05).
A trend towards reduced antihistamine use in the SCG group was observed, though not statistically significant.

Conclusions:

Sodium cromoglycate (SCG) is an effective treatment for seasonal allergic conjunctivitis induced by ragweed pollen.
SCG demonstrates significant symptom relief and patient-reported improvement in allergic conjunctivitis.