Flush with insight: Decoding GPCR crosstalk in the spinal defecation center
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Updated: Sep 18, 2025

In Vivo Calcium Imaging of Dorsal Root Ganglia Neurons' Response to Somatic and Visceral Stimuli
Published on: March 1, 2024
Nil Casajuana-Martin1, Eli F McDonald1, M Madan Babu1
1Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Abstract:
G protein-coupled receptors (GPCRs) are increasingly recognized as part of interconnected, cell-context-specific signaling networks. In the June 5th issue of Molecular Cell, Dehkhoda et al.1 demonstrate that the constitutive activity of the ghrelin receptor drives dopamine D2 receptor-dependent calcium mobilization, highlighting the complexity of GPCR signaling and opening new avenues for therapeutic development.
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