Related Experiment Video
Updated: Sep 18, 2025
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
Published on: December 15, 2010
Intra-arterial chemotherapy for retinoblastoma: a performance analysis
Yehonatan Weinberger1,2, Saloni Kapoor3, Emily C Zabor4
1Department of Ocular oncology, Cole eye institute, Cleveland Clinic, Cleveland, Ohio, USA.
Intra-arterial chemotherapy (IAC) shows a 73% overall globe salvage rate in retinoblastoma treatment. However, factors like study site, size, and year did not significantly impact outcomes, suggesting a need for better patient selection criteria.
Area of Science:
- Ophthalmology
- Oncology
- Chemotherapy
Background:
- Intra-arterial chemotherapy (IAC) is a treatment for retinoblastoma.
- Assessing the performance of IAC is crucial for optimizing treatment strategies.
Purpose of the Study:
- To perform a comprehensive performance analysis of intra-arterial chemotherapy (IAC) for retinoblastoma.
- To evaluate factors influencing globe salvage rates (GSR) in IAC treatment.
Main Methods:
- A systematic literature search was conducted in MEDLINE up to December 2023.
- Meta-analysis included 43 studies (3174 eyes), assessing heterogeneity and study variables.
- Performance was evaluated based on learning curve, experience, and study characteristics (site, size, year).
Main Results:
- The overall globe salvage rate (GSR) was 73% (95% CI 68-77%).
- GSR was comparable for primary (69%) and secondary (66%) IAC.
- Higher GSR was observed in International Classification of Retinoblastoma Group D (66%) compared to Group E (49%) eyes.
Conclusions:
- Improved selection criteria are necessary to identify suitable candidates for IAC.
- No significant impact on GSR was found related to study site income, size, or year of publication.
More Related Videos
04:48Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
09:49Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
Published on: December 2, 2013