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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Sep 18, 2025

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
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Published on: May 10, 2012

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Human neuroimaging: fMRI.

Matthew B Wall1, Robin L Carhart-Harris2

  • 1Perceptive Inc., Hammersmith Hospital, London, United Kingdom; Centre for Psychedelic Research, Division of Brain Sciences, Imperial College London, London, United Kingdom.

International Review of Neurobiology
|June 20, 2025
PubMed
Summary
This summary is machine-generated.

Functional Magnetic Resonance Imaging (fMRI) reveals classic psychedelics like psilocybin disrupt brain connectivity, impacting subjective experiences and long-term clinical effects. Further research requires standardized data and sharing for mechanistic understanding.

Keywords:
DMTFMRIFunctional magnetic resonance imagingLSDNeuroimagingNeuropsychopharmacologyPsilocybinPsychedelics

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Medical Imaging

Background:

  • Functional Magnetic Resonance Imaging (fMRI) is central to contemporary psychedelic research in healthy and clinical groups.
  • Classic psychedelics (psilocybin, LSD, DMT) acutely disrupt typical brain connectivity patterns.
  • This disruption is linked to subjective psychedelic experiences and clinical effects on emotional brain systems.

Purpose of the Study:

  • To outline the methodological background of fMRI in psychedelic research.
  • To review current knowledge on psychedelic drug actions using fMRI.
  • To discuss limitations and future directions in psychedelic neuroimaging.

Main Methods:

  • Review of task-based and resting-state fMRI studies.
  • Analysis of neuroimaging data in non-clinical and clinical populations.
  • Overview of fMRI methodology relevant to psychedelic research.

Main Results:

  • Psychedelics profoundly alter resting-state brain connectivity.
  • fMRI data links connectivity changes to subjective and clinical outcomes.
  • Current research highlights the role of fMRI in understanding psychedelic mechanisms.

Conclusions:

  • fMRI is a crucial tool for modern psychedelic research.
  • Standardization, data sharing, and multimodal studies are needed to advance the field.
  • Neuroimaging findings inform the mechanistic understanding and clinical development of psychedelics.