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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
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When inflammatory bowel disease meets pregnancy.
Shiqing Zhao1, Shengpu Zhou1, Junmei Wang2
1Research Centre of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China.
European Journal of Internal Medicine
|June 20, 2025
Summary
This review covers inflammatory bowel disease (IBD) management in pregnant women, focusing on treatment safety and the impact of early life on offspring with IBD.
Area of Science:
- Gastroenterology
- Reproductive medicine
- Immunology
Background:
- Inflammatory bowel disease (IBD) affects many women of reproductive age.
- Pregnancy in IBD patients presents unique management challenges.
- Safety of novel IBD treatments during pregnancy is a growing concern.
Purpose of the Study:
- To review the complex interplay between pregnancy and IBD.
- To outline specialized management strategies for IBD during pregnancy.
- To examine the long-term effects of early life exposures on offspring with IBD.
Main Methods:
- Literature review of current research on IBD and pregnancy.
- Synthesis of data on treatment efficacy and safety.
- Analysis of studies on perinatal factors influencing IBD development in offspring.
Main Results:
- Pregnancy can alter IBD course, requiring tailored management.
- Evidence supports the safety of many established and novel IBD therapies during pregnancy.
- Early life environmental factors may play a role in IBD pathogenesis in offspring.
Conclusions:
- Optimized IBD management during pregnancy is crucial for maternal and fetal outcomes.
- Careful consideration of treatment safety is paramount.
- Further research is needed on the developmental origins of IBD in children born to mothers with IBD.
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