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Related Experiment Video

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Using superDimension as navigation when performing cryobiopsies: a randomised-controlled study.

Sissel Kronborg-White1, Line Bille Madsen2, Torben Riis Rasmussen1

  • 1Centre for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.

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|June 20, 2025
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Summary
This summary is machine-generated.

SuperDimension (SD)-guided transbronchial cryobiopsy (TBCB) improved biopsy targeting and diagnostic contribution for interstitial lung disease (ILD) compared to fluoroscopy (FS). Both methods showed similar safety profiles for ILD diagnosis.

Keywords:
CryobiopsiesElectromagnetic navigationInterstitial lung diseasesInvasive pulmonology

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Area of Science:

  • Pulmonology
  • Medical Imaging
  • Interventional Pulmonology

Background:

  • Interstitial lung disease (ILD) diagnosis often necessitates invasive transbronchial cryobiopsy (TBCB).
  • Fluoroscopy (FS) is the conventional imaging guidance for TBCB.
  • Electromagnetic navigation (EMN) systems, such as superDimension (SD), offer potential for enhanced precision in TBCB procedures.

Purpose of the Study:

  • To compare complication rates, diagnostic yield, and biopsy quality between FS-guided and SD-guided TBCB in patients with suspected ILD.
  • To evaluate the efficacy of SD navigation in reaching difficult biopsy targets for ILD diagnosis.

Main Methods:

  • A prospective, randomized study design was employed.
  • Patients with ILD and challenging biopsy targets were randomized to either FS-guided or SD-guided TBCB.
  • Key outcomes measured included procedure time, complication rates, diagnostic yield, and biopsy quality.

Main Results:

  • SuperDimension (SD)-guided TBCB resulted in significantly higher rates of biopsies taken from the planned target (93% vs. 41%) and greater contribution to the final diagnosis (93% vs. 61%) compared to fluoroscopy (FS).
  • While SD-guided procedures were longer (62 vs. 44 min), there were no significant differences in complication rates or overall diagnostic yield between the two methods.
  • Biopsy quality and diagnostic contribution were notably improved with SD guidance.

Conclusions:

  • SuperDimension (SD) navigation demonstrates potential advantages for TBCB in specific ILD clinical scenarios, particularly for precise targeting.
  • Both FS- and SD-guided TBCB exhibit comparable safety profiles, making them suitable options based on lesion characteristics.
  • Further large-scale research is warranted to fully elucidate the benefits of SD-guided TBCB in ILD diagnosis.