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Related Experiment Videos

On the interaction between phenytoin and digoxin.

H Rameis

    European Journal of Clinical Pharmacology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Coadministration of phenytoin significantly reduces digoxin

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacology
    • Drug Interactions

    Background:

    • Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
    • Phenytoin is an anticonvulsant medication.
    • Potential drug interactions between digoxin and phenytoin require investigation.

    Purpose of the Study:

    • To investigate the pharmacokinetic interaction between phenytoin and digoxin at steady state.
    • To determine the effect of phenytoin on digoxin's elimination half-life, clearance, and volume of distribution.
    • To assess the impact of digoxin on phenytoin's pharmacokinetic parameters.

    Main Methods:

    • An open, randomized, single-blind, crossover trial.
    • Conducted in 6 healthy male volunteers.

    Related Experiment Videos

  • Involved coadministration of phenytoin and digoxin at steady state.

    • Main Results:

    • Phenytoin significantly reduced digoxin's elimination half-life (33.9 to 23.7 h) and AUC0-48 (31.6 to 24.4 ng X ml-1 X h).
    • Total digoxin clearance increased significantly (258.6 to 328.3 ml X min-1) with phenytoin coadministration.
    • No significant changes were observed in the pharmacokinetic parameters of phenytoin during coadministration with digoxin.

    Conclusions:

    • Phenytoin significantly increases digoxin clearance, leading to reduced serum digoxin concentrations.
    • Careful monitoring of serum digoxin levels and potential dose adjustments are recommended when coadministering phenytoin and digoxin.
    • The interaction primarily affects digoxin, with minimal impact on phenytoin pharmacokinetics.