Related Experiment Video
Updated: Sep 18, 2025
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Association between triglyceride-glucose index and intracranial aneurysm rupture: findings from a retrospective study
Jiancheng Lin1, Xin Feng1, Zhuohua Wen1
1Neurosurgery Center, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Background:
Limited studies investigated the relationship between triglyceride-glucose (TyG) index and the rupture of intracranial aneurysm (IA). We aimed to examine the association between TyG index and IA rupture in patients diagnosed with IAs.
Materials And Methods:
Participants with IAs from January 2012 to April 2022 were retrospectively included. The association between TyG index and IA rupture was assessed by multivariable-adjusted logistic regression models, restricted cubic spline (RCS) models and subgroup analysis.
Results:
Among 1535 patients with 1901 IAs, 596 (31.4%) IA rupture cases occurred. The incidence of IA rupture rose along with elevated TyG index. The positive correlation persisted after adjusting for age, sex, and other covariates, with adjusted odds ratios of 1.64 (95% CI 1.26-2.14) and 1.85 (95% CI 1.41-2.42) for TyG index tertiles 2 and 3. RCS curves showed a linear trend of TyG index with the risk of IA rupture. In the subgroup analysis, similar relationships were observed across subgroups defined by age, sex, hypertension, TC and aneurysm size.
Conclusions:
There is a significant association between TyG index and the occurrence of IA rupture, indicating TyG index has the potential for risk assessment of IA rupture. Further prospective studies are warranted to validate its clinical utility.
Trial Registration:
ClinicalTrials.gov (NCT06456814). Registered on June 7, 2024.
More Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
11:58Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
01:26Aneurysm III: Interprofessional Care