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Area of Science:

  • Biomedical Imaging
  • Environmental Health
  • Materials Science

Background:

  • Microplastics pose significant health risks, but understanding their biological effects is limited by a lack of in vivo tracking methods.
  • Near-infrared II (NIR-II) fluorescence imaging offers enhanced tissue penetration for observing biological processes in living organisms.

Purpose of the Study:

  • To develop a NIR-II fluorescence imaging platform for dynamic visualization of microplastic behavior in living mammals.
  • To investigate the impact of microplastics on gastrointestinal motility and retention in mice.

Main Methods:

  • Development of a NIR-II fluorescence imaging platform using polystyrene microplastic particles.
  • Oral administration of fluorescent microplastics to healthy, constipated, and colitis mouse models.
  • Dynamic tracking of microplastic transit using high-frame-rate NIR-II imaging and hyperspectral imaging.

Main Results:

  • NIR-II imaging successfully visualized microplastic movement and quantified intestinal motility (0.51 ± 0.02 beats/sec) and transit velocity (1.3 ± 0.2 mm/s) in healthy mice.
  • Constipated and colitis models showed impaired peristalsis and prolonged microplastic retention.
  • Long-term exposure led to persistent microplastic retention in intestines and spleen.

Conclusions:

  • The developed NIR-II imaging platform enables dynamic tracking of microplastics in vivo, providing critical insights into their biological distribution and effects.
  • Microplastic ingestion significantly impacts gastrointestinal function and can lead to long-term organ retention.
  • This technology is crucial for understanding the health implications of microplastic exposure in mammals.