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Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Ca2+-independent secretion is dependent on cytoplasmic ATP in human platelets
Abstract:
The secretion evoked in human platelets by physiological agonists is an energy-requiring process that depends on the metabolic ATP pool. Diacylglycerol, phorbol ester and collagen evoke a secretory response, which is not associated with an increase of cell Ca2+ levels, and is attributed to activation of protein kinase C [(1983) Nature 305, 317-319]. The secretion evoked by these agonists decreased along with cytoplasmic ATP depletion in the same way that the thrombin-induced secretion did. The secretory response was restored by raising again the cytoplasmic ATP levels. These results support the idea that the secretory response takes place by the physiological ATP-dependent mechanisms rather than by membrane perturbations in these instances.
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