Related Experiment Video
Updated: Sep 18, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Lethal means management innovations in community pharmacies: A preimplementation study in 6 states
Background:
Suicide is a leading cause of death in the United States, and a common means is intentional overdose. Community pharmacists have endorsed using pharmacy technologies and services for lethal means management. However, little is known about the barriers and facilitators to implementation.
Objectives:
To identify implementation facilitators and barriers to novel lethal means management (LMM) innovations.
Methods:
The Consolidated Framework for Implementation Research was used to develop semi-structured interviews with rural community pharmacists in 6 states to explore innovative LMM strategies, including Medication Therapy Management for Suicidal Behavior Disorder (MTM-SBD), compliance packaging, monitoring of patients taking medications labeled for suicide risk, training pharmacy staff as suicide prevention gatekeepers, pharmacy staff referrals of patients to #988 or local services, limiting nonprescription medication package sizes and/or placing large quantity nonsteroidal anti-inflammatories behind the counter, naloxone distribution either with every opioid or to only high-risk patients, and distributing gun locks.
Results:
Pharmacists described in detail the site and community context relative to potential implementation of previously identified LMM strategies. Pharmacists from 19 stores in 6 states identified compliance packaging and MTM-SBD as most promising due to established and adaptable workflows and informatics systems, trained staff, reimbursement models, availability and low cost of supplies, trained pharmacy staff and potential patient demand. Barriers included lack of an MTM protocol, payment codes and insurance coverage for the indication of SBD or more generally, suicidal risk.
Conclusion:
The majority of rural community pharmacists endorsed more facilitators than barriers to MTM and compliance packaging for management of suicide risk. Barriers are limited to expansion of current payment models to include the indication.
Related Concept Videos
Drug Regulation
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Nonlinear Pharmacokinetics: Overview
Nonlinearity can arise due to the saturation of plasma protein-binding or...
Analysis of Population Pharmacokinetic Data
Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

