Hepatic steatosis with significant fibrosis is associated with preclinical carotid atherosclerosis in patients with type 1 diabetes
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Metabolic dysfunction-associated steatotic liver disease (MASLD) scores correlate with preclinical atherosclerosis in type 1 diabetes (T1D). Advanced liver fibrosis markers significantly increase carotid atherosclerosis risk in T1D patients.
Area Of Science
- Hepatology
- Cardiology
- Endocrinology
Background
- Type 1 diabetes (T1D) is associated with increased cardiovascular disease (CVD) risk.
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized as a comorbidity in T1D.
- The link between MASLD and subclinical atherosclerosis in T1D requires further investigation.
Purpose Of The Study
- To evaluate the association between non-invasive metabolic dysfunction-associated steatotic liver disease (MASLD) scores and preclinical atherosclerosis in individuals with type 1 diabetes (T1D).
- To determine if MASLD indicators, including steatosis and fibrosis, predict the presence of carotid atherosclerosis in a T1D cohort.
Main Methods
- A cross-sectional study included 679 T1D individuals aged ≥40 years or with diabetic kidney disease and/or ≥10 years of T1D duration with CVD risk factors.
- MASLD was assessed using Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), and FIB-4 scores, categorizing participants into no steatosis, steatosis, or steatosis + fibrosis groups.
- Preclinical atherosclerosis was evaluated via carotid ultrasonography to detect plaque presence.
Main Results
- The prevalence of steatosis and steatosis + fibrosis was substantial, varying by index used (e.g., 45.2% steatosis by HSI).
- Carotid plaque presence significantly correlated with steatosis/fibrosis markers (p < 0.01).
- The steatosis + fibrosis combination, particularly by HSI, was independently associated with carotid atherosclerosis (OR 1.97) after adjusting for conventional and T1D-specific risk factors.
Conclusions
- Hepatic fibrosis markers, identifiable through non-invasive MASLD scores, are significantly associated with increased carotid atherosclerosis in T1D.
- Non-invasive MASLD assessments can aid in identifying T1D patients at elevated risk for cardiovascular events.
- These findings highlight the importance of screening for liver disease in T1D management.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...