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RSL1D1 regulates lung adenocarcinoma progression by inhibiting NRF2 ubiquitination
Qingzhu Yang1, Chunyun Zhang1, Hang Zhang2
1College of Life Science and Agriculture Forestry, Qiqihar University, Qiqihar 161006, China.
Abstract:
RSL1D1, a member of the universal ribosomal protein uL1 family, plays a crucial role in various cellular processes. However, its involvement in cancer, particularly lung adenocarcinoma (LUAD), remains poorly understood. Our study reveals that RSL1D1 expression is significantly upregulated in LUAD and high levels of RSL1D1 are associated with poorer survival outcomes in LUAD patients. Functionally, RSL1D1 promotes LUAD cell proliferation by inhibiting NRF2 degradation. Intriguingly, RSL1D1 interacts with NRF2 and hinders its ubiquitination. These findings highlight the pivotal role of the RSL1D1/NRF2 regulatory axis in LUAD tumor progression, presenting a novel potential target for LUAD therapy.
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