Lung Transplantation in the Elderly: Is Age a Contraindication?
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View abstract on PubMed
Summary
This summary is machine-generated.Lung transplantation outcomes are similar in older recipients (65+) compared to younger patients short-term. Advanced age shows acceptable long-term survival, with careful selection improving results.
Area Of Science
- Cardiology
- Pulmonology
- Transplant Surgery
Background
- Increasing prevalence of elderly patients undergoing lung transplantation.
- Need to explore outcomes in older age groups for lung transplant recipients.
Purpose Of The Study
- To compare lung transplantation outcomes in older versus younger patient groups.
- To evaluate the impact of advanced recipient age on short- and long-term survival.
Main Methods
- Retrospective review of bilateral lung transplantation records from April 2007 to March 2023.
- Comparison of patient characteristics and outcomes using univariate and multivariate analyses.
- Stratification of patients into age groups: 15-64, 65-69, 70-74, and 75-79 years.
Main Results
- Older recipients showed higher rates of male sex, White race, and restrictive lung disease.
- Younger recipients more frequently required ventilatory support pre-transplant.
- One-year survival was similar across age groups (15-74 years); median survival decreased with advanced age.
- Five-year survival rates ranged from 44.5% to 58.0%, with older groups showing slightly lower rates.
Conclusions
- Short-term outcomes for lung transplantation are similar between recipients aged 65 and older and younger patients.
- Advanced recipient age is linked to less favorable but acceptable long-term survival.
- Careful selection of older lung transplant recipients can improve perioperative outcomes and short-term survival.
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