Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

811
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
811
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

81
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
81
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.8K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.8K
Autoimmune Disorders01:29

Autoimmune Disorders

666
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
666
The Endocrine System01:29

The Endocrine System

533
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
533

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

microGLYMPH: a conceptual translational roadmap for microdialysis‑based assessment of CSF-interstitial solute exchange in acquired brain injury.

Critical care (London, England)·2026
Same author

Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care.

Critical care (London, England)·2026
Same author

Collision tumors at the skull base: unveiling a somatotroph pituitary adenoma coexisting with a petroclival meningioma. Illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Huntingtin knockdown dysregulates autophagic degradation of Apolipoprotein E.

Journal of Huntington's disease·2025
Same author

Management of positive cerebrospinal fluid cultures from intraventricular reservoirs of neuronal ceroid lipofuscinosis type 2 patients: one institution's experience.

Journal of neurosurgery. Pediatrics·2025
Same author

Balancing safety and efficacy: Assessment of a weight-based, anti-Xa-guided enoxaparin venous thromboembolism prophylaxis dosing strategy for traumatic brain injury patients.

The journal of trauma and acute care surgery·2025

Related Experiment Video

Updated: Sep 8, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

14.8K

Endocrinopathy and Dysautonomia.

Gianna M Fote1, Alexander S Himstead1, Jefferson W Chen1

  • 1Department of Neurological Surgery, University of California, Irvine, 200 South Manchester Avenue, Suite 210, Orange, CA 92868, USA.

Neurosurgery Clinics of North America
|June 21, 2025
PubMed
Summary
This summary is machine-generated.

Traumatic brain injury (TBI) and spinal cord injury can cause hormonal imbalances and autonomic nervous system dysfunction. Early identification and long-term monitoring of hormone levels are crucial for managing these complex conditions.

Keywords:
Adrenal insufficiencyDysautonomiaEndocrinopathyPitiutarySpinal cord injuryTraumatic brain injury

More Related Videos

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.4K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.6K

Related Experiment Videos

Last Updated: Sep 8, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

14.8K
Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.4K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.6K

Area of Science:

  • Neuroendocrinology
  • Neurology
  • Trauma Surgery

Background:

  • Traumatic brain injury (TBI) frequently leads to endocrinopathies impacting multiple hypothalamic-pituitary axes.
  • TBI and spinal cord injury (SCI) can cause dysautonomia due to damage to neural structures.
  • Spinal shock following SCI presents a significant risk of morbidity and mortality.

Purpose of the Study:

  • To highlight the critical endocrine and autonomic dysfunctions following TBI and SCI.
  • To emphasize the importance of timely assessment and management of these conditions.
  • To outline the necessity of long-term monitoring for chronic deficiencies.

Main Methods:

  • Review of endocrine and autonomic sequelae in TBI and SCI patients.
  • Analysis of hormonal axes affected, including hypothalamic-pituitary-adrenal (HPA), antidiuretic hormone (ADH), and thyroid function.
  • Evaluation of diagnostic and management strategies for acute and chronic phases.

Main Results:

  • Endocrinopathies affect all major hypothalamic-pituitary hormone axes post-TBI.
  • Dysautonomia is a common complication, linked to sympathetic structure or spinal cord injury.
  • Long-term monitoring of growth hormone, thyroid hormone, gonadotropins, and cortisol is essential to prevent adverse metabolic and cognitive effects.

Conclusions:

  • Management of HPA axis, ADH, and thyroid function is critical in the acute phase of TBI.
  • Chronic hormone deficiencies require ongoing monitoring to mitigate long-term complications.
  • Early identification and management of spinal shock are vital for improving outcomes in SCI patients.