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Updated: Sep 8, 2025

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity
Published on: September 1, 2023
Application of bacterial extracellular vesicles in gastrointestinal diseases
Yajun Wang1, Menghang Zu1, Baoyi Li1
1Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
Abstract:
Bacterial extracellular vesicles (BEVs) are nanoscale spherical particles with lipid bilayer membranes containing diverse functional components from their parent bacteria. They exert pivotal effects on bacteria-bacteria and host-bacteria communication. Analyzing the dynamic changes in the production and composition of BEVs provides insights into the relationship between gut microbiota and host health, offering valuable perspectives for diagnosing various gastrointestinal diseases. Furthermore, BEVs can be employed as natural medications and drug delivery vehicles for inflammation management, cancer treatment, and vaccine development. This review summarizes the structural composition, generation mechanism, and biomedical applications of BEVs, emphasizing recent advances in immune regulation, gut microbiota modulation, and the clinical translation challenges associated with gastrointestinal diseases.
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