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Time-Dependent Apparent Diffusion Coefficient Changes in Breast MR Images With Contrast for Tumor Characterization.

Yongsheng Ao1, Xuanle Li2, Lan Mu3

  • 1Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Medical Imaging Center, The Second People's Hospital of Yibin, Yibin, China.

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|June 21, 2025
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Summary

Scan time after contrast injection minimally impacts apparent diffusion coefficient (ADC) values in breast MRI diffusion-weighted imaging (DWI). This finding supports using postcontrast DWI for accurate differentiation of benign from malignant breast lesions.

Keywords:
Breast tumorContrast agent impactContrast agent injection timingDiagnostic accuracyDiffusion-weighted imaging

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Breast MRI diffusion-weighted imaging (DWI) is crucial for lesion characterization.
  • Apparent diffusion coefficient (ADC) values are key metrics in DWI analysis.
  • Understanding the impact of contrast timing on ADC is essential for diagnostic accuracy.

Purpose of the Study:

  • To evaluate how scan timing post-contrast injection affects breast MRI DWI ADC values.
  • To determine the role of these time-dependent ADC changes in differentiating breast lesions.

Main Methods:

  • Analysis of 251 breast MRI scans from 251 patients with 258 lesions.
  • Measurement of ADC values at precontrast, 3 minutes, and 6 minutes postcontrast.
  • Application of statistical methods including ROC analysis and DeLong test for lesion differentiation.

Main Results:

  • Contrast injection transiently decreases ADC values within 3 minutes, with partial recovery by 6 minutes.
  • ADC values effectively distinguish between benign tumors and malignant cancers.
  • ADC differentiation capability is not affected by time-dependent changes postcontrast.

Conclusions:

  • Contrast injection timing has minimal impact on the diagnostic performance of ADC in differentiating benign from malignant breast lesions.
  • Postcontrast DWI sequences can be utilized without compromising diagnostic accuracy for breast lesion assessment.