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Updated: Sep 8, 2025

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
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Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

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GPR17 - orphan G protein-coupled receptor with therapeutic potential

Michael Lewash1, Evi Kostenis2, Christa E Müller1

  • 1PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.

Trends in Pharmacological Sciences
|June 21, 2025
PubMed
Summary

The G protein-coupled receptor (GPCR) GPR17 shows promise for treating multiple sclerosis (MS) by enabling remyelination. New research and drug candidates like PTD802 offer hope for MS therapies and other neurodegenerative diseases.

Keywords:
G-protein-coupled receptorGPR17agonistsantagonistsmultiple sclerosisremyelination

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