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IL-17B Inhibits Hepatocellular Carcinoma Cell Proliferation.

Joanna Pastwińska¹, Iwona Karwaciak¹, Kaja Karaś¹

¹Laboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.

Archivum Immunologiae Et Therapiae Experimentalis

|June 22, 2025

Summary

Interleukin-17B (IL-17B) inhibits hepatocellular carcinoma (HCC) cell proliferation via an AKT-dependent pathway. This discovery offers a potential new therapeutic strategy for HCC, a liver cancer with limited treatment options.

Keywords:

Hepatocellular carcinoma IL-17B IL-17RB Proliferation

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Area of Science:

Immunology
Oncology
Molecular Biology

Background:

Interleukin-17 receptor B (IL-17RB) is a receptor for IL-17B and IL-17E.
IL-17RB is highly expressed in hepatocellular carcinoma (HCC) cells at both mRNA and protein levels.

Purpose of the Study:

To investigate the effect of IL-17B on HCC cell proliferation.
To elucidate the underlying molecular mechanism of IL-17B's action in HCC.

Main Methods:

Analysis of IL-17RB expression in cancer cell lines.
Cell proliferation assays.
Colony formation assays.
Investigation of signaling pathways (AKT and NF-κB).

Main Results:

IL-17B significantly inhibits the proliferation of HCC cells.
The inhibitory effect of IL-17B on HCC cells is mediated by an AKT-dependent pathway.
IL-17B also affects colony formation in HCC cells.
These effects were not observed in melanoma cells with low IL-17RB expression.

Conclusions:

IL-17B acts as a tumor suppressor in HCC through the IL-17RB receptor.
The IL-17B-IL-17RB signaling pathway presents a potential therapeutic target for HCC treatment.
Further research into this pathway could lead to novel immunotherapies for liver cancer, considering its role in liver regeneration.