Related Experiment Video
Updated: Sep 18, 2025
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid-stimulating immunoglobulin is not associated with aggressive clinicopathologic features in concomitant
Brendan M Finnerty1, Teagan Marshall1, Chandler A Annesi2
1Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, 525 E68th Street, New York, NY, 10065, United States.
Background:
Graves' disease has been associated with increased tumor aggressiveness in differentiated thyroid carcinoma, however, its correlation with thyroid stimulating immunoglobulin (TSI) remains unclear.
Methods:
A tri-institutional retrospective review of 96 thyroidectomy patients with Graves' disease and papillary thyroid carcinoma (PTC) was performed (2002-2020). Clinicopathologic features and recurrence were compared based on TSI level.
Results:
ATA risk stratification distribution was low (72.9 %), intermediate (14.6 %), and high (12.5 %). Recurrence rate was 11.5 % with median follow-up of 3.2 years. TSI was not associated with high-risk clinicopathologic features at its 50 % and 75 % quartiles. There was no difference in median TSI between patients with recurrence versus no recurrence [212 (IQR 98-361) vs. 327 (IQR 152-461), p = 0.148]. TSI was not associated with recurrence on univariable Cox regression, even when excluding microcarcinomas.
Conclusions:
In this majority low-risk PTC cohort with concomitant Graves' disease, TSI level is not associated with aggressive clinicopathologic features or recurrence.
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