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'Emerging cell-specific therapies in cardiovascular disease'
Amandeep Rashid Mondal1, Ashish Misra2
1Atherosclerosis and Vascular Remodeling Group, Heart Research Institute, Sydney, NSW, Australia; Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Vascular Pharmacology
|June 22, 2025
Summary
New cell-specific therapies target atherosclerosis by modulating plaque cell behavior. These innovative approaches, including nanoparticles and CRISPR-Cas9, offer precise treatments for cardiovascular disease.
Area of Science:
- Cardiovascular Research
- Cellular Biology
- Biotechnology
Background:
- Atherosclerosis is a major global cause of cardiovascular disease.
- Current treatments focus on risk factors, not underlying plaque progression.
- Key cell types (endothelial cells, macrophages, smooth muscle cells) drive plaque development.
Purpose of the Study:
- To review innovative cell-specific therapeutic strategies for atherosclerosis.
- To explore the potential of emerging technologies in treating cardiovascular disease.
- To consider repurposing oncology treatments for atherosclerosis.
Main Methods:
- Review of nanoparticle-based therapies.
- Analysis of viral vector applications in atherosclerosis.
- Evaluation of CRISPR-Cas9 gene editing for plaque modulation.
Main Results:
- Cell-specific therapies offer precise targeting of atherosclerotic plaque cells.
- Nanoparticles, viral vectors, and CRISPR-Cas9 can modulate gene expression and cell behavior.
- Insights from oncology suggest potential for repurposing treatments.
Conclusions:
- Emerging cell-specific therapies hold promise for more effective atherosclerosis treatment.
- These approaches aim to address the cellular roots of cardiovascular disease.
- Personalized treatment options with reduced off-target effects are anticipated.
