Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

240
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
240
Positron Emission Tomography01:29

Positron Emission Tomography

5.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology.

Nature communications·2026
Same author

Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Associations of Anthropometry Measures Across 35 Years With Late-Life Plasma P-tau217 and Dementia: The HUNT Study.

Neurology·2026
Same author

Genetically prioritized druggable targets for amyloid-β pathology highlight <i>ACE</i> as a therapeutic candidate in Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Speech Recognition-Based Dietary Assessment Tool for Older Adults: Validation and Usability Study.

JMIR aging·2026
Same journal

Association of sleep duration with Alzheimer's disease and cognition.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Plasma-based neurobiological protein biomarkers as predictors of dementia progression: Insights from longitudinal aging study in India - Diagnostic assessment of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

368

Integrating visual assessments and quantification methods for tau PET staging.

Yuna Gu1,2, Jihwan Yun3, Alexis Moscoso4,5,6

  • 1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|June 22, 2025
PubMed
Summary
This summary is machine-generated.

Visual and quantification methods for tau positron emission tomography (PET) staging offer complementary strengths. Quantification methods show promise in detecting early tau burdens and correlate with cognitive decline, enhancing staging accuracy.

Keywords:
Alzheimer's diseaseamyloid–tau stagingcognitive trajectoriesdiagnostic precisionphosphorylated tau217plasma biomarkersquantitative methodstau positron emission tomography stagingtemporal meta‐regiontemporoparietal regionvisual assessment

More Related Videos

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

12.9K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

549

Related Experiment Videos

Last Updated: Sep 18, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

368
PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

12.9K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

549

Area of Science:

  • Neuroimaging and Biomarkers
  • Alzheimer's Disease Research

Background:

  • Accurate staging of Alzheimer's disease (AD) pathology is crucial for clinical trials and patient management.
  • Tau positron emission tomography (PET) is a key imaging modality for assessing neurofibrillary tangle accumulation in AD.

Purpose of the Study:

  • To compare visual assessment and quantitative analysis methods for tau PET staging.
  • To evaluate plasma biomarkers and cognitive trajectories across amyloid and tau (AT) staging.
  • To validate findings across independent cohorts.

Main Methods:

  • Tau PET scans from the Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD) cohort (n=289) were analyzed visually and quantitatively.
  • Validation was performed using the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (n=870).
  • Plasma biomarkers and cognitive measures were assessed across AT stages.

Main Results:

  • FreeSurfer without partial volume correction (PVC) showed the highest accuracy (AUC=0.918) for visual tau positivity detection.
  • Temporal and temporoparietal regions of interest demonstrated high performance in moderate (AUC=0.856) and advanced (AUC=0.828) tau staging, respectively.
  • Quantitative methods effectively detected changes in phosphorylated tau217 during intermediate AT transitions and correlated with cognitive decline.

Conclusions:

  • Both visual and quantitative tau PET methods have complementary strengths for staging Alzheimer's disease.
  • Quantitative methods offer advantages in detecting early tau pathology and correlate with plasma biomarkers and cognitive decline.
  • The findings were consistently observed in both K-ROAD and ADNI cohorts, highlighting the robustness of the results.