Lamotrigine and anti-seizure medications in HLH: A systematic review

Lamotrigine and other anti-seizure medications have been reported to cause both haemophagocytic lympho-histiocytosis (HLH) and drug-induced hypersensitivity syndrome (DIHS). HLH and DIHS have many characteristic clinical, laboratory, pathological findings and underlying mechanisms; we identified significant clinical overlap between these two syndromes in our systematic review. Of note, the presence of haemophagocytosis on bone marrow biopsy, while supportive, is not exclusive to or synonymous with a diagnosis of HLH.