Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

4.5K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
4.5K
What is the Skeletal System?01:02

What is the Skeletal System?

53.7K
Overview
53.7K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K
Bone Remodeling01:40

Bone Remodeling

38.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.6K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eating behaviours, prevalence of obesity & health policies.

International journal of food sciences and nutrition·2026
Same author

Response to Letter Fat<sub>max</sub> Testing in Obesity: The Need for Outcome Validation and Real-World Integration.

Journal of obesity & metabolic syndrome·2026
Same author

Bisphenol A induces a pro-angiogenic-like phenotype via the G protein-coupled receptor 30 (GPR30) pathway.

Scientific reports·2026
Same author

Ketogenic and Low-Carbohydrate Diets in Prostate Cancer: Metabolic Rationale, Preclinical Evidence, and Preliminary Clinical Data.

Journal of clinical medicine·2026
Same author

Current application and future directions for the sarcopenic obesity Global Leadership Initiative (SOGLI) diagnostic algorithm.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Psychometric Properties of the Italian Food Noise Questionnaire (FNQ) for the Assessment of Intrusive Food-Related Thoughts.

Behavioral sciences (Basel, Switzerland)·2026

Related Experiment Video

Updated: Sep 18, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

524

Sarcopenia and osteoporosis.

Edoardo Mocini, Claudia Piciocchi, Giuseppe Defeudis

    Gerontology
    |June 23, 2025
    PubMed
    Summary

    Osteoporosis and sarcopenia are common in older adults, increasing fall risks. Integrated treatments combining nutrition, exercise, and medication can improve bone and muscle health, reducing fractures and enhancing quality of life.

    Area of Science:

    • Gerontology
    • Musculoskeletal Health
    • Aging Research

    Background:

    • Sarcopenia (loss of muscle mass and strength) and osteoporosis (reduced bone density and quality) frequently coexist in aging populations.
    • These conditions contribute to frailty, disability, and an increased risk of falls and fractures.
    • The combined clinical syndrome is termed osteosarcopenia.

    Purpose of the Study:

    • To discuss the shared pathophysiology of sarcopenia and osteoporosis.
    • To emphasize the significance of early diagnosis and integrated management strategies.
    • To explore therapeutic interventions for preserving musculoskeletal health in older adults.

    Main Methods:

    • Review of common risk factors including chronic inflammation, oxidative stress, and hormonal changes.

    More Related Videos

    Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
    13:35

    Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

    Published on: March 21, 2021

    10.8K
    Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
    04:00

    Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

    Published on: July 26, 2024

    682

    Related Experiment Videos

    Last Updated: Sep 18, 2025

    The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
    03:52

    The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

    Published on: February 21, 2025

    524
    Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
    13:35

    Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

    Published on: March 21, 2021

    10.8K
    Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
    04:00

    Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

    Published on: July 26, 2024

    682
  • Analysis of nutritional interventions: adequate protein, vitamin D, and calcium intake.
  • Evaluation of exercise interventions: resistance training.
  • Examination of pharmacological treatments: bisphosphonates, selective androgen receptor modulators (SARMs), and myostatin inhibitors.

    • Main Results:

    • Shared risk factors accelerate musculoskeletal deterioration.
    • Nutritional and exercise strategies are crucial for maintaining muscle and bone health.
    • Pharmacological options offer promising therapeutic avenues for sarcopenia and osteoporosis.
    • A combined approach can mitigate fall and fracture risks.

    Conclusions:

    • Osteosarcopenia presents a significant health challenge in aging populations.
    • Integrated therapeutic strategies targeting both muscle and bone are essential.
    • Early diagnosis and multifaceted interventions can improve functional outcomes and quality of life.