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Development and validation of a nomogram combining cytokines with traditional clinical parameters in predicting the risk of postoperative sepsis after ureteroscopic lithotripsy

  • 0Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Renal Failure +

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June 23, 2025

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June 23, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

A new nomogram predicts sepsis risk after ureteroscopic lithotripsy (URSL) surgery. This tool combines routine tests with cytokine levels for improved preoperative patient assessment and reduced septic complications.

Area Of Science

  • Urology
  • Infectious Disease
  • Medical Diagnostics

Background

  • Sepsis is a severe complication of ureteroscopic lithotripsy (URSL).
  • Current risk assessment for postoperative sepsis requires urgent updates.
  • Predicting and preventing sepsis is crucial for patient outcomes after URSL.

Purpose Of The Study

  • To develop a novel nomogram for predicting septic complications after URSL.
  • To improve preoperative risk stratification for patients undergoing URSL.
  • To reduce the incidence of postoperative sepsis in URSL patients.

Main Methods

  • Retrospective review of 333 patients undergoing URSL.
  • Analysis of routine blood/urine parameters and cytokine concentrations (IL-6, IL-8, IL-10, IFN-γ).
  • Development and validation of a predictive nomogram using logistic regression, ROC, and DCA.

Main Results

  • A nomogram incorporating preoperative antibiotic use, CRP, albumin, LDH, IL-6, IL-8, IL-10, IFN-γ, and urine protein was created.
  • The nomogram demonstrated strong discriminative ability (AUC = 0.981).
  • Decision curve analysis confirmed the nomogram's clinical utility for risk evaluation.

Conclusions

  • A validated nomogram effectively predicts postoperative sepsis risk after URSL.
  • This tool integrates traditional parameters with cytokine levels for enhanced accuracy.
  • The nomogram can aid in surgical risk assessment and clinical decision-making to prevent sepsis.

Keywords:

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