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[Local administration of tranexamic acid for prevention and treatment of bleeding]

Jeppe Hjembæk-Brandt1,2, Mathias Maagaard3, Christine Nygaard Svendsen2

  • 1Afdeling for Plastikkirurgi, Københavns Universitetshospital - Herlev Hospital.

Ugeskrift for Laeger
|June 23, 2025
PubMed

Tranexamic acid (TXA) is an antifibrinolytic drug found on WHO's list of "essential medicines". TXA is effective in reducing bleeding by 30-40% in a wide range of clinical scenarios and is most often administered systemically. Concerns regarding increased risk of thromboembolic events have prompted research into local administration of TXA. Local administration of TXA has therefore been investigated in a wide range of clinical scenarios with most studies showing an effect approximately equal to systemically administrated TXA and with minimal risk of systemic side effects, as argued in this review.

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