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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Acute Kidney Injury V: Interprofessional Care01:20

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

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Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Nephrotic Syndrome III : Nursing Management01:24

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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[New s in nephroprotection].

Florence Sens1, Maurice Laville1, Laure Groisne2

  • 1Association pour l'utilisation du rein artificiel en région lyonnaise (AURAL), Lyon, France.

La Revue Du Praticien
|June 23, 2025
PubMed
Summary
This summary is machine-generated.

Recent advances in nephroprotection, including sodium-glucose cotransport type II inhibitors (iSGLT2), offer new ways to preserve kidney function and slow chronic kidney disease progression in adults.

Keywords:
Renal Insufficiency, Chronic

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Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Nephroprotection strategies aim to preserve kidney function and slow chronic kidney disease (CKD) progression.
  • Therapeutic options have expanded significantly, potentially reducing the incidence of end-stage renal failure.

Purpose of the Study:

  • To provide an overview of recent advancements in cardio-nephroprotection for adult patients with CKD.
  • To emphasize the role and application of sodium-glucose cotransport type II inhibitors (iSGLT2), also known as gliflozins.

Main Methods:

  • Review of recent therapeutic advances in nephroprotection.
  • Focus on pharmacological interventions including iSGLT2, glucagon-like peptide-1 analogues, and non-steroidal mineralocorticoid receptor antagonists.
  • Consideration of conventional strategies like lifestyle modifications and renin-angiotensin-aldosterone system blockers.

Main Results:

  • Significant expansion of therapeutic options for CKD management.
  • iSGLT2 inhibitors, GLP-1 analogues, and non-steroidal MRAs are key among new treatments.
  • Integration of these novel agents with established therapies offers improved cardio-nephroprotective effects.

Conclusions:

  • Recent advances, particularly iSGLT2 inhibitors, represent a major step forward in preserving kidney function.
  • These therapies are crucial for slowing CKD progression and improving cardiovascular outcomes in affected adults.
  • Understanding the specific roles and conditions for using iSGLT2 inhibitors is vital for effective clinical practice.