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[New s in nephroprotection]

Florence Sens1, Maurice Laville1, Laure Groisne2

  • 1Association pour l'utilisation du rein artificiel en région lyonnaise (AURAL), Lyon, France.

La Revue Du Praticien
|June 23, 2025
PubMed

Insights

Recent advances in nephroprotection, including sodium-glucose cotransport type II inhibitors (iSGLT2), offer new ways to preserve kidney function and slow chronic kidney disease progression in adults.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Nephroprotection strategies aim to preserve kidney function and slow chronic kidney disease (CKD) progression.
  • Therapeutic options have expanded significantly, potentially reducing the incidence of end-stage renal failure.

Purpose of the Study:

  • To provide an overview of recent advancements in cardio-nephroprotection for adult patients with CKD.
  • To emphasize the role and application of sodium-glucose cotransport type II inhibitors (iSGLT2), also known as gliflozins.

Main Methods:

  • Review of recent therapeutic advances in nephroprotection.
  • Focus on pharmacological interventions including iSGLT2, glucagon-like peptide-1 analogues, and non-steroidal mineralocorticoid receptor antagonists.
  • Consideration of conventional strategies like lifestyle modifications and renin-angiotensin-aldosterone system blockers.

Main Results:

  • Significant expansion of therapeutic options for CKD management.
  • iSGLT2 inhibitors, GLP-1 analogues, and non-steroidal MRAs are key among new treatments.
  • Integration of these novel agents with established therapies offers improved cardio-nephroprotective effects.

Conclusions:

  • Recent advances, particularly iSGLT2 inhibitors, represent a major step forward in preserving kidney function.
  • These therapies are crucial for slowing CKD progression and improving cardiovascular outcomes in affected adults.
  • Understanding the specific roles and conditions for using iSGLT2 inhibitors is vital for effective clinical practice.
Keywords:
Renal Insufficiency, Chronic

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