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Updated: Sep 18, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Cholestatic Hepatic Injury Induced by Carbimazole: A Case Report and a Thorough Literature Review
Bassem Al Hariri1,2,3, Mohammed Omer Elbadawi Elhassan4, Hadil Altaj Altrify Alsidig4
1Department of Medicine Hamad Medical Corporation Doha Qatar.
Abstract:
Carbimazole, a thionamide derivative, is widely used for hyperthyroidism but carries a rare risk of hepatotoxicity, including cholestatic injury. A 42-year-old man developed severe cholestatic jaundice 4 weeks after carbimazole initiation. Laboratory findings showed marked hyperbilirubinemia (peak: 650 μmol/L) with elevated ALP (366 U/L). Viral, autoimmune, and biliary causes were excluded. Liver biopsy confirmed cholestasis. Carbimazole was discontinued, corticosteroids initiated, and radioiodine therapy planned. Bilirubin levels gradually improved over 8 weeks. Carbimazole-induced cholestasis, though rare, necessitates prompt recognition and alternative hyperthyroidism management. Routine liver monitoring is crucial.
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