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Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
Published on: October 17, 2013
The impact of pregnancy on bioprosthetic structural valve deterioration: a systematic review and meta-analysis
Gianna L Wilkie1, Evelyn Semenov1, Katherine Leung1
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Abstract:
Objective: This systematic review and meta-analysis sought to assess the impact of pregnancy on bioprosthetic valve (BPV) structural valve deterioration. Methods: We searched Ovid MEDLINE, Scopus, Clinicaltrials.gov, and Cochrane Library from inception through October 17, 2022. We included all studies that compared patients with BPV with and without a pregnancy history. The initial search yielded 1748 unique citations that were screened in Covidence by two independent reviewers. Our outcome of interest was structural valve deterioration. Results: We performed random-effects meta-analyses from nine eligible studies. Meta-analysis of 321 individuals with a pregnancy history and 987 control individuals without pregnancy showed there was an increased odds in development of structural valve deterioration among those with a pregnancy history (OR 2.34, 95% CI 1.40-3.89) with an I 2 of 59.8%. Conclusions: A pregnancy history was associated with an increased risk of structural valve deterioration; however, further research is needed due to the heterogeneity of results.
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