Cytoplasmic and nuclear programmed death ligand 1 expression in peritumoral stromal cells in breast cancer: Prognostic and predictive value
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View abstract on PubMed
Summary
This summary is machine-generated.Assessing programmed death ligand 1 (PD-L1) expression in breast cancer (BC) stromal cells, specifically the PDCD1 LG1-positive lymphocyte (PDCD1 LG1+ LF) score, alongside lymphovascular invasion (LVI), improves prediction of metastasis to regional lymph nodes (RLNs).
Area Of Science
- Oncology
- Immunology
- Pathology
Background
- Breast cancer (BC) remains a leading cause of cancer mortality in women.
- Programmed death ligand 1 (PD-L1) is a key marker in BC progression.
- Previous studies focused on PD-L1 in tumor cells; its role in stromal cells requires further investigation.
Purpose Of The Study
- To investigate programmed cell death protein 1 ligand 1 (PDCD1 LG1) expression in BC stromal cells.
- To determine the relationship between PDCD1 LG1 expression in stromal cells and BC clinicopathological characteristics.
Main Methods
- Prospective observational study of 148 newly diagnosed BC patients.
- Immunohistochemical staining for PDCD1 LG1 on tumor samples.
- Assessment of PDCD1 LG1 expression in lymphocytes, polymorphic cell infiltrates, fibroblastic stroma, and endothelial cells.
Main Results
- PDCD1 LG1+ lymphocyte (PDCD1 LG1+ LF) score ≥ 3 was more frequent in stages N0 and N3.
- PDCD1 LG1+ infiltrates and fibroblastic stroma correlated with negative estrogen receptor status, HER2-positive BC, and specific BC subtypes.
- Regional lymph node (RLN) metastasis risk depends on lymphovascular invasion (LVI) and PDCD1 LG1+ LF score.
Conclusions
- Combined assessment of PDCD1 LG1+ LF score and LVI enhances prediction accuracy for RLN metastasis in BC patients.
- This combined approach offers improved prognostic value for BC management.
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