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Updated: Sep 18, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Right-sided descending colon with necrotizing enterocolitis: a rare case report.

Ting Wang¹, Shunlin Xia¹, Mengxu Liu¹

¹Huai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Huai'an, China.

Frontiers in Pediatrics

|June 23, 2025

Summary

A rare case of right-sided descending colon in a newborn led to necrotizing enterocolitis (NEC). Surgical intervention was successful, highlighting the importance of recognizing colonic anatomical variations.

Keywords:

case report end ileostomy necrotizing enterocolitis (NEC)newborn right-sided descending colon

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Area of Science:

Gastroenterology
Pediatric Surgery
Anatomical Pathology

Background:

Anatomical variations of the colon are well-documented, predominantly affecting the right side.
Anomalies of the left colon, especially the descending colon, are infrequently reported in medical literature.

Observation:

A newborn presented with vomiting and gastroesophageal reflux, with imaging revealing a right-sided descending and sigmoid colon.
The infant later developed necrotizing enterocolitis (NEC), necessitating surgical intervention after conservative treatment failed.

Findings:

The descending colon was noted to be fixed to the posterior abdominal wall, extending rightward and crossing the midline.
The colon showed dilation, thickened walls, mucosal ulceration, and transmural necrosis, with severe involvement of the descending and sigmoid colon.
Pathology confirmed significant inflammatory cell infiltration.

Implications:

This case underscores the critical need for surgeons to be aware of potential descending colon positional variations.
Considering such anatomical anomalies preoperatively is vital for enhancing surgical safety and preventing iatrogenic colonic injury.