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Updated: Sep 18, 2025

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In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
Published on: June 8, 2022
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Right-sided descending colon with necrotizing enterocolitis: a rare case report
Ting Wang1, Shunlin Xia1, Mengxu Liu1
1Huai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Huai'an, China.
Frontiers in Pediatrics
|June 23, 2025
Summary
A rare case of right-sided descending colon in a newborn led to necrotizing enterocolitis (NEC). Surgical intervention was successful, highlighting the importance of recognizing colonic anatomical variations.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Anatomical Pathology
Background:
- Anatomical variations of the colon are well-documented, predominantly affecting the right side.
- Anomalies of the left colon, especially the descending colon, are infrequently reported in medical literature.
Observation:
- A newborn presented with vomiting and gastroesophageal reflux, with imaging revealing a right-sided descending and sigmoid colon.
- The infant later developed necrotizing enterocolitis (NEC), necessitating surgical intervention after conservative treatment failed.
Findings:
- The descending colon was noted to be fixed to the posterior abdominal wall, extending rightward and crossing the midline.
- The colon showed dilation, thickened walls, mucosal ulceration, and transmural necrosis, with severe involvement of the descending and sigmoid colon.
- Pathology confirmed significant inflammatory cell infiltration.
Implications:
- This case underscores the critical need for surgeons to be aware of potential descending colon positional variations.
- Considering such anatomical anomalies preoperatively is vital for enhancing surgical safety and preventing iatrogenic colonic injury.
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