Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early ultrastructural changes in RU-486-exposed decidua.

A M Schindler, P Zanon, D Obradovic

    Gynecologic and Obstetric Investigation
    |January 1, 1985
    PubMed
    Summary

    Mifepristone (RU-486) administration in early pregnancy interruption showed no placental lesions. Decidual tissue exhibited edema and necrosis, with ultrastructural capillary endothelial changes in RU-486 treated patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prognostic impact of acute kidney injury on one-year survival in patients undergoing high-risk PCI with Impella support.

    Scientific reports·2026
    Same author

    The global extent of the grassland biome and implications for the terrestrial carbon sink.

    Nature ecology & evolution·2026
    Same author

    Novel computational modeling of trimodal chromatographic retention using Box-Cox and multivariate analysis.

    Journal of chromatography. A·2025
    Same author

    Computational modelling of detected persistent organic pollutants in adriatic pelagic fish: molecular and toxicokinetic perspectives for human health risk assessment.

    SAR and QSAR in environmental research·2025
    Same author

    [Moderately hypofractionated dose escalation radiotherapy for localized prostate cancer, ESHYPRO: Results of a retrospective single-centre series evaluating safety and efficacy].

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
    Same author

    [Proposal for the delineation of postoperative primary clinical target volumes in maxillary sinus and nasal cavity cancers].

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024

    Area of Science:

    • Reproductive Endocrinology
    • Pharmacology
    • Histopathology

    Background:

    • The antiprogesterone mifepristone (RU-486) is used for voluntary pregnancy interruption.
    • Understanding its effects on maternal tissues is crucial for safety and efficacy assessments.

    Purpose of the Study:

    • To investigate the morphological effects of mifepristone on placental and decidual tissues in women undergoing early pregnancy termination.
    • To correlate observed histological changes with mifepristone dosage and potential mechanisms of action.

    Main Methods:

    • Comparative morphological study using light and electron microscopy.
    • Histopathological examination of placental and decidual tissues from three groups: control, mifepristone 100 mg once, and mifepristone 200 mg divided dose.
    • Morphometric analysis of decidual capillary endothelium.

    Related Experiment Videos

    Main Results:

    • No significant pathological changes were observed in placental tissues.
    • Decidual tissues showed non-specific edema and necrosis, with more pronounced stromal disintegration in mifepristone-treated groups.
    • Ultrastructural examination revealed significant endothelial hyperplasia of the endoplasmic reticulum in decidual capillaries of the 200 mg mifepristone group compared to controls.

    Conclusions:

    • Mifepristone treatment at the studied doses did not cause specific placental lesions.
    • Observed decidual changes, particularly ultrastructural endothelial alterations, may be linked to prostaglandin synthesis induction by mifepristone.
    • The full clinical significance of these morphological findings regarding the abortifacient effect of mifepristone remains undetermined.