Advantages of new generation colonoscopes on adenoma detection: A propensity-score matching study

Recently, Olympus Corporation released new scopes (XZ1200/EZ1500). However, there have been few reports on this topic, although improvement in adenoma detection rate (ADR) by texture and color enhancement imaging (TXI) or computer-aided detection system (CAD) has been reported.

To investigate the effects of the scope on the detection of adenomas and sessile serrated lesions (SSLs).

The subjects were patients who underwent pancolonic chromoendoscopy using the EVIS X1 video system center between May 2023 and October 2024. The patients were divided into the new (CF-XZ1200/CF-EZ1500) and 290 series (CF-HQ290Z/PCF-H290Z) groups. Propensity score matching was performed for age, sex, examination purpose, endoscopist, preparation, TXI use, and CAD use. The effects of the scope were analyzed in terms of the ADR, SSL detection rate (SDR), and mean number of adenomas per colonoscopy (APC).

Of the 7014 patients enrolled, 2138 pairs were extracted by propensity score matching (mean age 55.4 years, 45.5% male). The new scopes group had a significantly higher ADR than the 290 series group [51.5% vs 45.5%, odds ratio (OR) = 1.27, 95%CI: 1.13-1.43, P < 0.001]. Similarly, the new scopes group had significantly higher SDR (7.8% vs 5.7%, OR = 1.41, 95%CI: 1.11-1.80, P = 0.005) and APC (0.90 vs 0.76, OR = 1.11, 95%CI: 1.05-1.17, P < 0.001) than the 290 series group.

In conclusion, the new scope (CF-XZ1200/CF-EZ1500) enhanced the detection of adenomas and SSLs compared to the old ones (290 series).