Green and Sustainable Synthesis of Biaryls Using LaPO₄·Pd Recyclable Nanocatalyst by the Suzuki-Miyaura Coupling in...

Herein, we report the synthesis of novel LaPO₄·Pd nanocatalyst, characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), and X-ray photoelectron spectroscopy (XPS) studies. The newly prepared nanocatalyst has been utilized as an efficient catalyst for synthesizing biaryls through Suzuki-Miyaura cross-coupling reactions of haloarenes and phenylboronic acids. The salient features of the protocol include the aqueous medium synthesis of biaryls, broad substrate scope, high yield of the products, gram-scale synthesis of biaryl 3a, recyclability, and reusability of the nanocatalyst for five consecutive runs without significant loss in its catalytic efficiency and yield. The aforementioned features account for the green and sustainable aspect of the protocol in the biaryl synthesis.