Polysaccharide-Encapsulated Lauraceae Extract Complex Coating Conferring Antimicrobial Properties to Polypropylene...

The rise in antimicrobial resistance (AMR) pathogens necessitates innovative approaches for infection control, particularly in medical device applications. Moreover, simultaneously ensuring sustained antimicrobial activity in biomaterials and minimizing potential resistance development remain critical aspects that lack new strategies. This study presents the development and application of an innovative antimicrobial agent, that is, a multifunctional polysaccharide-encapsulated Lauraceae extract complex (PLEC) coating designed to enhance the antimicrobial efficacy and compatibility of polypropylene surfaces. The study findings indicate that the PLEC coating has potent antibacterial and antifungal characteristics, preventing a wide range of infections. A comprehensive analysis revealed significant reductions in bacterial colonies, including colonies of Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), Gram-positive bacteria (Staphylococcus aureus and Streptococcus mitis), and various fungal strains. Moreover, cytotoxicity evaluations confirm the nontoxic nature of the coatings, ensuring their safety for medical use. This study demonstrates that multifunctional antimicrobial PLEC coatings offer a significant advancement in infection control strategies, providing an effective solution to the growing problem of AMR. The developed approach can be beneficial to the healthcare industry and society by reducing infection risks and treatment costs, ultimately improving clinical effectiveness and enhancing the efficacy of infection control measures in medical applications.