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Updated: Sep 18, 2025

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
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Future perspectives: targeting fibroblast growth factor receptor 1 to enhance the efficacy of immunotherapy

Ilya Tsimafeyeu1

  • 1Bureau for Cancer Research - BUCARE, New York, NY 10032, USA.

Exploration of Targeted Anti-Tumor Therapy
|June 23, 2025
PubMed

Insights

Targeting Fibroblast Growth Factor Receptor 1 (FGFR1) can overcome cancer immune evasion and resistance to immune checkpoint inhibitors (ICIs). Combining FGFR1 inhibitors with ICIs shows promise for enhancing antitumor activity and T cell responses.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Fibroblast Growth Factor Receptor 1 (FGFR1) is crucial in cancer progression, influencing cell proliferation, survival, and differentiation.
  • FGFR1 is increasingly recognized for its role in cancer immune evasion and resistance to immune checkpoint inhibitors (ICIs).

Purpose of the Study:

  • To explore the role of FGFR1 in cancer biology and its contribution to immunotherapy resistance.
  • To investigate the therapeutic potential of targeting FGFR1 to enhance the efficacy of ICIs.

Main Methods:

  • Review of preclinical studies investigating FGFR1's role in cancer.
  • Analysis of the impact of FGFR1 inhibition on the tumor microenvironment and immune responses.
  • Evaluation of combination therapies involving FGFR1 inhibitors and ICIs.

Main Results:

  • FGFR1 inhibition can alter the tumor microenvironment and counteract immune suppression.
  • Combining FGFR1 inhibitors (e.g., OM-RCA-01) with ICIs significantly improves antitumor activity in preclinical models.
  • Enhanced T cell responses and cytokine production were observed with combination therapy.

Conclusions:

  • Targeting FGFR1 represents a promising strategy to enhance the effectiveness of current immunotherapies.
  • Combination therapy of FGFR1 inhibitors and ICIs holds potential for improving cancer treatment outcomes.
Keywords:
Fibroblast growth factor receptor 1anti-FGFR1 antibodyimmune checkpoint inhibitorsresistance

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