Dose-dependent L-arginine cardiotoxicity in diabetic cardiomyopathy: Mechanisms and clinical implications

This letter addresses the study in recent publication in the World Journal of Diabetes. The study provides valuable insights and a comprehensive analysis of the effects of L-arginine (L-Arg) supplementation on cardiac health in diabetic rats, highlighting the potential risks associated with high doses of L-Arg. The findings suggest that while low doses of L-Arg may offer some benefits, higher doses can exacerbate myocardial injury through increased oxidative stress, inflammation, and structural disruption. This finding challenges the prevailing point of L-Arg as a universally beneficial supplement and emphasizes the need for further research in its clinical application, particularly in diabetic patients.