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Hyperprolactinemia and sexual function in men.

J Buvat, A Lemaire, M Buvat-Herbaut

    Hormone Research
    |January 1, 1985
    PubMed
    Summary
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    Male hyperprolactinemia (HPRL) can cause sexual dysfunction. This study found HPRL in 1.1% of men with erectile impotence and 10% with premature ejaculation, highlighting the need for prolactin testing in sexual dysfunction cases.

    Area of Science:

    • Endocrinology
    • Urology
    • Sexual Medicine

    Background:

    • Male hyperprolactinemia (HPRL) is associated with various sexual dysfunctions.
    • The incidence and impact of HPRL on male sexual health require further investigation.

    Purpose of the Study:

    • To determine the incidence of HPRL in men presenting with sexual dysfunction.
    • To explore the relationship between HPRL, testosterone levels, and sexual function in men.
    • To investigate the efficacy of prolactin reduction in treating HPRL-induced sexual dysfunction.

    Main Methods:

    • Serum prolactin (PRL) levels were assayed in 1053 men with clinically idiopathic sexual dysfunction.
    • Patients with erectile impotence, premature ejaculation, anejaculation, and reduced libido were analyzed.

    Related Experiment Videos

  • Sexual behavior and hormone levels (PRL, testosterone) were monitored before and during bromocriptine treatment in HPRL patients.

    • Main Results:

    • Marked HPRL (PRL > 35 ng/ml) was found in 1.1% of men with erectile impotence (10/850), with 6 cases linked to pituitary adenoma.
    • Mild HPRL (PRL 20-35 ng/ml) was detected in 2% of men with erectile impotence and 10% of those with premature ejaculation (13/124).
    • Erectile function improved in 6 out of 17 HPRL patients during bromocriptine treatment, preceding significant testosterone level increases.

    Conclusions:

    • Serum prolactin testing is crucial for all men with idiopathic erectile impotence, as testosterone levels may be normal.
    • HPRL can cause sexual dysfunction independently of low testosterone levels.
    • Reducing prolactin levels with bromocriptine can restore sexual function in some men with HPRL, even before testosterone normalization.