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Transient Elastography Increases Readiness for Change in Inpatients With Alcohol Use Disorder: The ELISA Pilot Study.

Stephanie M Rutledge1,2, Rohit R Nathani3, Patricia Miguez Arosemena3

  • 1Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Addiction Biology
|June 23, 2025
PubMed
Summary
This summary is machine-generated.

Transient elastography (TE) as an opportunistic intervention for alcohol use disorder (AUD) significantly increased patient motivation and readiness for change. This pilot study also efficiently detected advanced liver fibrosis in AUD patients.

Keywords:
alcohol‐associated liver diseasefibrosismotivationopportunistic interventionopportunistic screening

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Area of Science:

  • Hepatology
  • Addiction Medicine
  • Psychology

Background:

  • Opportunistic interventions (OIs) leverage healthcare encounters to motivate risk-reducing behaviors.
  • Transient elastography (TE) is a non-invasive method to assess liver fibrosis.
  • Patients with alcohol use disorder (AUD) often have co-occurring liver disease and may benefit from interventions that enhance motivation for change.

Purpose of the Study:

  • To evaluate transient elastography (TE) as an opportunistic intervention (OI) in patients with AUD.
  • To assess changes in psychometric scores (PS) related to alcohol insight and readiness for change after TE.
  • To determine the prevalence of liver fibrosis and steatosis in this patient population.

Main Methods:

  • A prospective, proof-of-concept pilot study enrolled 23 inpatients with severe AUD.
  • Validated psychometric scores (Hanil Alcohol Insight Scale, revised Readiness Ruler, SOCRATES-8A) were administered at baseline and after TE.
  • TE was performed, results interpreted, and secondary outcomes included fibrosis/steatosis prevalence and linkage to hepatology care.

Main Results:

  • Significant increases in revised Readiness Ruler (5 to 8.6, p<0.01) and SOCRATES-8A (81.5 to 85.0, p=0.04) scores were observed, indicating enhanced motivation and readiness for change.
  • The Hanil Alcohol Insight Scale score did not significantly change (11.1 to 11.0, p=0.36).
  • TE detected cirrhosis in 17% (4/23) and significant steatosis (grade ≥2) in 35% (8/23) of patients.

Conclusions:

  • Performing and interpreting TE in inpatients with AUD serves as an effective opportunistic intervention.
  • TE increases patient motivation and readiness for behavioral change regarding alcohol consumption.
  • This approach efficiently identifies advanced liver fibrosis in individuals with AUD, facilitating timely hepatology referral.