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Updated: Sep 18, 2025

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Pd(II)-Catalyzed Dehydrogenative Annulation of 2-Arylimidazo[1,2-a]Pyridines with Maleimides: Regioselectivity Switch
Hemant Joshi1, Krishna Yadav2, Suman Mahala2
1Department of Chemistry, Malaviya National Institute of Technology Jaipur, Jaipur, Rajasthan, 302017, India.
Abstract:
Herein, we report a palladium(II)-catalyzed dehydrogenative annulation of 2-arylimidazo[1,2-a]pyridines with maleimides, representing the first example of the regioselectivity reversal for this class of substrates. Notably, the transformation proceeds efficiently with a low catalyst loading (1.5 mol%). A plausible reaction mechanism is proposed, supported by control experiments and in situ HRMS analysis. Photophysical investigations of the annulated products reveal moderate to high quantum yields, highlighting their potential for optoelectronic applications. Furthermore, these molecules demonstrate promising sensitivity as picric acid-sensing probes.
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