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A Simple and Rapid Fluorescent Sensor Based on MoS2 Quantum Dots for Dopamine Detection.

Yunbo Zhao1, Fangyuan Yang2, Lefa Zhao3

  • 1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Journal of Fluorescence
|June 23, 2025
PubMed
Summary

Molybdenum disulfide quantum dots (MoS2 QDs) offer a new fluorescent sensor for dopamine (DA) detection. This simple method effectively quantifies DA in urine, showing high selectivity and recovery.

Keywords:
Dopamine detectionElectron transferFluorescent sensingInner filter effectMoS2 quantum dots

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Dopamine (DA) is a crucial neurotransmitter implicated in various physiological and pathological processes.
  • Accurate and sensitive detection of DA in biological samples is essential for clinical diagnostics and research.
  • Existing DA detection methods can be complex, time-consuming, or lack sufficient sensitivity and selectivity.

Purpose of the Study:

  • To develop a simple, rapid, and sensitive fluorescent sensing platform for dopamine detection.
  • To utilize molybdenum disulfide quantum dots (MoS2 QDs) as a fluorescent probe for dopamine analysis.
  • To investigate the sensing mechanism and assess the sensor's performance in complex biological matrices.

Main Methods:

  • Synthesis of MoS2 QDs using a one-step hydrothermal method.
  • Establishment of a fluorescence quenching-based sensing platform for dopamine detection.
  • Investigation of the synergistic effects of inner filter effect (IFE) and electron transfer (ET) in the sensing mechanism.
  • Optimization of the sensing conditions and evaluation of analytical performance, including linearity, detection limit, selectivity, and stability.

Main Results:

  • MoS2 QDs were successfully synthesized and exhibited fluorescence properties.
  • Dopamine (DA) caused fluorescence quenching of MoS2 QDs via IFE and ET mechanisms upon oxidation to dopamine quinone under alkaline conditions.
  • The optimized sensor demonstrated a linear response for DA detection in the range of 200-600 µM with a high correlation coefficient (R2 = 0.9980).
  • A low detection limit of 4 µM was achieved, along with high selectivity for DA over other interfering substances.
  • The sensor showed excellent performance in spiked recovery tests in human urine samples, with recoveries ranging from 95% to 104.6%.

Conclusions:

  • The developed MoS2 QD-based fluorescent sensor provides a simple, rapid, and highly sensitive method for dopamine detection.
  • The synergistic IFE and ET mechanisms contribute to the efficient fluorescence quenching of MoS2 QDs by dopamine.
  • The sensor's stability, ease of preparation, and successful application in human urine samples highlight its potential for practical DA analysis in complex biological fluids.