Risk factors for chemotherapy-induced oral mucositis in cancer patients: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Identifying risk factors for chemotherapy-induced oral mucositis (CIOM) is key. Poor oral hygiene, smoking, and specific chemotherapy regimens increase CIOM risk in cancer patients.
Area Of Science
- Oncology
- Evidence-based Medicine
- Systematic Review
Background
- Chemotherapy-induced oral mucositis (CIOM) is a common and debilitating side effect of cancer treatment.
- Identifying modifiable and non-modifiable risk factors is crucial for effective prevention and management strategies.
Purpose Of The Study
- To systematically review and meta-analyze the factors influencing the risk of chemotherapy-induced oral mucositis in cancer patients.
- To identify key risk factors for CIOM through a comprehensive literature search and statistical analysis.
Main Methods
- A systematic literature search was performed across multiple databases up to August 2024.
- Meta-analysis was conducted using RevMan5.4 software to assess risk factors (Odds Ratios and 95% Confidence Intervals).
- Study quality was evaluated using the Newcastle-Ottawa Scale and AHRQ criteria, with evidence grading by GRADEpro GDT.
Main Results
- Ten studies involving 2365 cancer patients were included, with six high-quality and four moderate-quality studies.
- Significant risk factors for CIOM included a history of oral disease, combination chemotherapy, smoking history, poor oral hygiene, and specific chemotherapy regimens (5-FU/methotrexate).
Conclusions
- Several independent risk factors for chemotherapy-induced oral mucositis have been identified.
- Early screening and prompt intervention for patients with identified risk factors are essential for reducing CIOM incidence and improving patient outcomes.
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