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Updated: Sep 18, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Ethnicity Risk and Exertional Rhabdomyolysis: A Narrative Review.

Angela Nguyen¹, Austin Thomassen¹, Ellie M MacDonald¹

¹School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.

Advances in Therapy

|June 23, 2025

Summary

Exertional rhabdomyolysis (ER) disproportionately affects African Americans with sickle cell trait due to genetic and social factors. Targeted prevention and improved healthcare access are crucial for at-risk minority communities.

Keywords:

ER Ethnicity risk Exertional rhabdomyolysis Skeletal muscle injury

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Last Updated: Sep 18, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

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Published on: December 11, 2016

A Preclinical Model of Exertional Heat Stroke in Mice

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Functional Characterization of Endogenously Expressed Human RYR1 Variants

Functional Characterization of Endogenously Expressed Human RYR1 Variants

Published on: June 9, 2021

Area of Science:

Exercise physiology
Genetics
Public health

Background:

Exertional rhabdomyolysis (ER) involves skeletal muscle breakdown after intense activity, releasing harmful substances.
ER can lead to acute kidney injury, electrolyte imbalances, and potentially death if untreated.

Purpose of the Study:

To review the pathophysiology, risk factors, and complications of ER.
To examine the influence of ethnicity, specifically sickle cell trait and social determinants of health, on ER development and severity.

Main Methods:

Narrative review of existing literature.
Analysis of studies including genome-wide association, retrospective cohort, and population-based research.
Examination of observational research and military health data.

Main Results:

Sickle cell trait, particularly in African Americans, increases ER risk due to red blood cell sickling under stress.
Limited healthcare access, poor nutrition, and social challenges exacerbate ER risk in minority communities.
Consistent evidence shows racial and ethnic disparities in ER outcomes, with disproportionate impact on African Americans with sickle cell trait.

Conclusions:

Further research is needed to elucidate genetic and social factors influencing ER.
Addressing research gaps is vital for improving clinical care, guiding future studies, and enhancing patient education.
Developing targeted prevention strategies and improving healthcare access for high-risk populations is essential for equitable ER management.