Related Experiment Video
Updated: Sep 18, 2025
07:13
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
4.5K
Health Care Resource Utilization and Costs of Major Adverse Thrombotic Events in Patients with and without ESKD
Nicholas S Roetker1, Alejandro Victores2, Chuanyu Kou1
1Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota.
Kidney360
|June 23, 2025
Insights
Patients with end-stage kidney disease (ESKD) on dialysis experience significantly higher healthcare costs and resource use from major adverse thrombotic events (MATEs) compared to those without ESKD. Reducing MATEs in dialysis patients is crucial for managing healthcare utilization and costs.
Area of Science:
- Nephrology
- Cardiology
- Health Economics
Background:
- Major adverse thrombotic events (MATEs) are a significant cause of morbidity and mortality in patients with end-stage kidney disease (ESKD) on dialysis.
- Limited data exists on the comparative healthcare resource utilization (HCRU) and costs of MATEs between dialysis and non-dialysis populations.
Purpose of the Study:
- To compare HCRU and costs associated with MATEs in older adults with ESKD receiving dialysis versus those without ESKD.
- To inform strategies for managing MATEs in the dialysis population.
Main Methods:
- An observational cohort study of fee-for-service Medicare beneficiaries aged ≥66 years experiencing a first MATE (2015-2018).
- Comparison of individuals with ESKD on dialysis (in-center hemodialysis [ICHD] and home dialysis) against individuals without ESKD.
- MATEs identified via claims-based algorithms; outcomes included HCRU and Medicare payments during index event and 1-year follow-up.
- Age-, sex-, and race-adjusted outcomes estimated using model-based standardization; maintenance dialysis costs excluded.
Main Results:
- Index MATE hospitalizations were 1.2-1.3 times longer and 1.2-1.5 times costlier for ICHD patients versus non-ESKD patients.
- One-year follow-up showed 2-3 times higher rates and costs of subsequent MATE-related hospitalizations in ICHD patients compared to non-ESKD patients.
- HCRU and costs for home dialysis patients were generally similar to or higher than ICHD patients.
Conclusions:
- Dialysis patients experiencing MATEs incur greater HCRU and costs than non-dialysis patients.
- Reducing HCRU and costs associated with MATEs is a critical treatment goal for dialysis patients.
- Findings highlight the substantial economic and resource burden of MATEs in the ESKD population.
Abstract
No abstract available in PubMed .
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
28
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
28
01:28Chronic Kidney Disease III: Interprofessional Care
84
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
84
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
924
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
924
01:30Venous Thrombosis IV: Nursing Management
27
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
27
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
48
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
48
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
64
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
64